The Mental Health Center and the Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Psychiatry Res. 2012 Aug 15;198(3):353-9. doi: 10.1016/j.psychres.2012.01.020. Epub 2012 Mar 16.
Using the Structured Clinical Interview for DSM-IV, patient and non-patient version (SCID-P/NP), this study investigated 351 patients with schizophrenia, 122 with obsessive-compulsive disorder (OCD), and 238 unrelated healthy volunteers in a Chinese Han population. The relative risks posed by advanced paternal age for schizophrenia and OCD in offspring were computed under logistic regression analyses and adjusted for the participant's sex, age and co-parent age at birth. Compared to the offspring with paternal age of 25-29 years old, the relative risks rose from 2.660 to 10.183 in the paternal age range of 30-34 and ≥35. The relative risks for OCD increased from 2.225 to 5.413 in 30-34 and ≥35. For offspring with paternal age of <25, the odds ratios of developing schizophrenia and OCD were 0.628 and 0.289 respectively, whereas an association between increased maternal age and risk for schizophrenia/OCD was not seen. Interaction analysis showed an interaction effect between paternal age and maternal age at birth. Such a tendency of risk affected by parental age for schizophrenia and OCD existed after splitting out the data of early onset patients. Sex-specific analyses found that the relative risks for schizophrenia with paternal age of 30-34 and ≥35 in male offspring were 2.407 and 10.893, and in female offspring were 3.080 and 9.659. The relative risks for OCD with paternal age of 30-34 and ≥35 in male offspring were 3.493 and 7.373, and in female offspring 2.005 and 4.404. The mean paternal age of schizophrenia/OCD patients born before the early 1980s was much greater than that of patients who were born after then. The findings illustrated that advanced paternal age is associated with increased risk for both schizophrenia and OCD in a Chinese Han population, prominently when paternal age is over 35. Biological and non-biological mechanisms may both be involved in the effects of advanced paternal age on schizophrenia and OCD.
本研究采用 DSM-IV 定式临床访谈患者版和非患者版（SCID-P/NP），对中国汉族人群中的 351 名精神分裂症患者、122 名强迫症（OCD）患者和 238 名无关健康志愿者进行了调查。在逻辑回归分析中计算了高龄父亲对子代精神分裂症和 OCD 的相对风险，并根据参与者的性别、年龄和同胞出生时的年龄进行了调整。与父亲年龄在 25-29 岁的后代相比，父亲年龄在 30-34 岁和≥35 岁范围内的相对风险从 2.660 上升到 10.183。OCD 的相对风险从 30-34 岁和≥35 岁的 2.225 上升到 5.413。对于父亲年龄<25 岁的后代，患精神分裂症和 OCD 的优势比分别为 0.628 和 0.289，而母亲年龄增加与精神分裂症/OCD 风险之间没有关联。交互分析显示，父亲年龄和母亲出生年龄之间存在交互作用。在排除早发性患者的数据后，这种由父母年龄对精神分裂症和 OCD 风险的影响趋势仍然存在。性别特异性分析发现，30-34 岁和≥35 岁的父亲年龄与男性后代的精神分裂症相对风险分别为 2.407 和 10.893，与女性后代的相对风险分别为 3.080 和 9.659。30-34 岁和≥35 岁的父亲年龄与男性后代的 OCD 相对风险分别为 3.493 和 7.373，与女性后代的相对风险分别为 2.005 和 4.404。出生于 20 世纪 80 年代以前的精神分裂症/OCD 患者的平均父亲年龄明显大于出生于 80 年代以后的患者。这些发现表明，高龄父亲与中国汉族人群中精神分裂症和 OCD 的风险增加有关，尤其是当父亲年龄超过 35 岁时。生物和非生物机制都可能参与了高龄父亲对精神分裂症和 OCD 的影响。
