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本文引用的文献

1
Autoradiographic study of cell migration during histogenesis of cerebral cortex in the mouse.小鼠大脑皮质组织发生过程中细胞迁移的放射自显影研究。
Nature. 1961 Nov 25;192:766-8. doi: 10.1038/192766b0.
2
Distribution of zincergic neurons in the mouse forebrain.锌能神经元在小鼠前脑的分布。
J Comp Neurol. 2004 Nov 8;479(2):156-67. doi: 10.1002/cne.20308.
3
The Tlx gene regulates the timing of neurogenesis in the cortex.Tlx基因调节皮质神经发生的时间。
J Neurosci. 2004 Sep 22;24(38):8333-45. doi: 10.1523/JNEUROSCI.1148-04.2004.
4
Expression of the transcription factor, tailless, is required for formation of superficial cortical layers.转录因子无尾的表达是表层皮质层形成所必需的。
Cereb Cortex. 2003 Sep;13(9):921-31. doi: 10.1093/cercor/13.9.921.
5
Thalamic distribution of zinc-rich terminal fields and neurons of origin in the rat.大鼠中富含锌的终末场及起源神经元的丘脑分布。
Neuroscience. 2001;102(4):863-84. doi: 10.1016/s0306-4522(00)00472-3.
6
Importance of zinc in the central nervous system: the zinc-containing neuron.锌在中枢神经系统中的重要性：含锌神经元。
J Nutr. 2000 May;130(5S Suppl):1471S-83S. doi: 10.1093/jn/130.5.1471S.
7
Sequence of neuron origin and neocortical laminar fate: relation to cell cycle of origin in the developing murine cerebral wall.神经元起源顺序与新皮质层命运：与发育中小鼠脑壁起源细胞周期的关系
J Neurosci. 1999 Dec 1;19(23):10357-71. doi: 10.1523/JNEUROSCI.19-23-10357.1999.
8
Experience-dependent alteration of synaptic zinc in rat somatosensory barrel cortex.大鼠体感桶状皮层中突触锌的经验依赖性改变。
Somatosens Mot Res. 1999;16(2):139-50. doi: 10.1080/08990229970573.
9
Experience-dependent alteration of zinc-containing circuits in somatosensory cortex of the mouse.
Brain Res Dev Brain Res. 1999 May 14;114(2):283-7. doi: 10.1016/s0165-3806(99)00042-5.
10
Zinc-rich afferents to the rat neocortex: projections to the visual cortex traced with intracerebral selenite injections.大鼠新皮质中富含锌的传入神经：通过脑内注射亚硒酸盐追踪到视觉皮质的投射。
J Chem Neuroanat. 1998 Aug;15(2):97-109. doi: 10.1016/s0891-0618(98)00035-0.

在缺乏转录因子无尾的情况下含锌皮质回路的异常发育。

Abnormal development of zinc-containing cortical circuits in the absence of the transcription factor Tailless.

作者信息

Land Peter W, Monaghan A Paula

机构信息

Department of Neurobiology, W1458 Biomedical Science Tower, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

出版信息

Brain Res Dev Brain Res. 2005 Aug 8;158(1-2):97-101. doi: 10.1016/j.devbrainres.2005.04.006.

DOI:10.1016/j.devbrainres.2005.04.006
PMID:15950290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2724001/
Abstract

Absence of the transcription factor tailless (tlx) leads to premature laminar development and thinning of neocortex. We used zinc autometallography to determine if tailless deletion alters the organization of cortical circuits. In tlx-/- mice, layer 4 barrels, which normally lack synaptic zinc, are densely innervated by zinc-containing terminals. Furthermore, barrels with zinc inputs are constructed, in part, from zinc-sequestering neurons, a phenotype not normally found in layer 4.

摘要

转录因子无尾（tlx）的缺失会导致新皮层的层状发育过早和变薄。我们使用锌自动放射自显影术来确定无尾缺失是否会改变皮质回路的组织。在tlx基因敲除小鼠中，通常缺乏突触锌的第4层桶状结构被含锌终末密集支配。此外，有锌输入的桶状结构部分由锌螯合神经元构成，这是第4层通常不会出现的一种表型。