神经干细胞及疾病中的孤儿核受体 TLX/NR2E1
The Orphan Nuclear Receptor TLX/NR2E1 in Neural Stem Cells and Diseases.
机构信息
Department of Intensive Care, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
出版信息
Neurosci Bull. 2016 Feb;32(1):108-14. doi: 10.1007/s12264-015-0004-7. Epub 2016 Jan 15.
Abstract
The human TLX gene encodes an orphan nuclear receptor predominantly expressed in the central nervous system. Tailess and Tlx, the TLX homologues in Drosophila and mouse, play essential roles in body-pattern formation and neurogenesis during early embryogenesis and perform crucial functions in maintaining stemness and controlling the differentiation of adult neural stem cells in the central nervous system, especially the visual system. Multiple target genes and signaling pathways are regulated by TLX and its homologues in specific tissues during various developmental stages. This review aims to summarize previous studies including many recent updates from different aspects concerning TLX and its homologues in Drosophila and mouse.
摘要
人类 TLX 基因编码一个主要在中枢神经系统表达的孤儿核受体。在果蝇和小鼠中，Tailess 和 Tlx 是 TLX 的同源物，它们在早期胚胎发生过程中的身体模式形成和神经发生中发挥重要作用，并在维持中枢神经系统（特别是视觉系统）中的干性和控制成年神经干细胞的分化方面发挥关键作用。在不同的发育阶段，TLX 及其同源物在特定组织中通过多个靶基因和信号通路进行调节。本综述旨在总结以前的研究，包括来自果蝇和小鼠的 TLX 及其同源物的多个最新更新。
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Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes.孤儿核受体TLX通过对CDKN1A（p21（WAF1）/（CIP1））和SIRT1基因的转录共调节，作为前列腺癌中癌基因诱导衰老的有效抑制因子发挥作用。
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