Gkikas Dimitrios, Tsampoula Matina, Politis Panagiotis K
Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Efesiou Str, 115 27, Athens, Greece.
Cell Mol Life Sci. 2017 Nov;74(22):4097-4120. doi: 10.1007/s00018-017-2571-4. Epub 2017 Jun 21.
In the central nervous system, embryonic and adult neural stem/progenitor cells (NSCs) generate the enormous variety and huge numbers of neuronal and glial cells that provide structural and functional support in the brain and spinal cord. Over the last decades, nuclear receptors and their natural ligands have emerged as critical regulators of NSC homeostasis during embryonic development and adult life. Furthermore, substantial progress has been achieved towards elucidating the molecular mechanisms of nuclear receptors action in proliferative and differentiation capacities of NSCs. Aberrant expression or function of nuclear receptors in NSCs also contributes to the pathogenesis of various nervous system diseases. Here, we review recent advances in our understanding of the regulatory roles of steroid, non-steroid, and orphan nuclear receptors in NSC fate decisions. These studies establish nuclear receptors as key therapeutic targets in brain diseases.
在中枢神经系统中，胚胎期和成年期的神经干细胞/祖细胞（NSCs）产生了种类繁多、数量巨大的神经元和神经胶质细胞，这些细胞为脑和脊髓提供结构和功能支持。在过去几十年中，核受体及其天然配体已成为胚胎发育和成年期NSC稳态的关键调节因子。此外，在阐明核受体在NSCs增殖和分化能力中的作用分子机制方面已经取得了实质性进展。NSCs中核受体的异常表达或功能也与各种神经系统疾病的发病机制有关。在此，我们综述了近期在理解类固醇、非类固醇和孤儿核受体在NSC命运决定中的调节作用方面的进展。这些研究确立了核受体作为脑部疾病关键治疗靶点的地位。
