Rodríguez-Sánchez José Manuel, Crespo-Facorro Benedicto, Perez-Iglesias Rocío, González-Blanch César, Alvarez-Jimenez Mario, Llorca Javier, Vázquez-Barquero José Luis
Hospital Universitario Marqués de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Planta 2(a), Edificio 2 de Noviembre. Avda. Valdecilla s/n, 39008 Santander, Spain.
Schizophr Res. 2005 Sep 15;77(2-3):279-88. doi: 10.1016/j.schres.2005.04.023.
Specific prefrontal cognitive impairments have been reported in first-episode and chronic schizophrenia. We sought to investigate potential impairments in specific prefrontal cortical cognitive functions among stabilized patients with a first-episode of schizophrenia. A sample of 80 individuals with a first-episode of schizophrenia spectrum disorders and 22 healthy volunteers underwent a neurocognitive battery assessing orbitofrontal (OFC) [The Iowa Gambling Task (GT)], and dorsolateral prefrontal (DLPFC) functions (WAIS III Backward digits, verbal fluency test (FAS), and Trail Making Test). Cognitive data were obtained following stabilization of acute psychotic symptoms. Clinical symptoms after six weeks of treatment were assessed by using the SAPS and SANS scales. While there were no significant group differences in overall scores and in the profile of progress of performance along periods on the GT, patient group showed a significant impairment when performing DLPFC tasks. Only FAS score was correlated to the severity of negative symptomatology. The OFC functions are unimpaired at the early phases of psychosis and in contrast there is a significant deficit in DLPFC functions in first-episode of schizophrenia.
在首发和慢性精神分裂症患者中均有特定前额叶认知障碍的报道。我们试图调查首发精神分裂症稳定期患者特定前额叶皮质认知功能的潜在损害。80例首发精神分裂症谱系障碍患者和22名健康志愿者接受了一组神经认知测试，评估眶额叶（OFC）[爱荷华赌博任务（GT）]和背外侧前额叶（DLPFC）功能（韦氏成人智力量表第三版数字倒背、言语流畅性测试（FAS）和连线测验）。在急性精神病症状稳定后获取认知数据。使用阳性与阴性症状量表（SAPS）和阴性症状评定量表（SANS）评估治疗六周后的临床症状。虽然在GT的总体得分以及各阶段表现进展的概况方面两组无显著差异，但患者组在执行DLPFC任务时表现出显著损害。只有FAS得分与阴性症状的严重程度相关。在精神病早期OFC功能未受损，相反，首发精神分裂症患者的DLPFC功能存在显著缺陷。
