（1H-咪唑并[4,5-c]吡啶-2-基）-1,2,5-恶二唑-3-基胺衍生物：一类新型强效MSK-1抑制剂。
(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors.
作者信息
Bamford Mark J, Alberti Michael J, Bailey Nicholas, Davies Susannah, Dean David K, Gaiba Alessandra, Garland Stephen, Harling John D, Jung David K, Panchal Terence A, Parr Christopher A, Steadman Jon G, Takle Andrew K, Townsend James T, Wilson David M, Witherington Jason
机构信息
GlaxoSmithKline Pharmaceuticals, Neurology and GI Centre of Excellence for Drug Discovery, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.
出版信息
Bioorg Med Chem Lett. 2005 Jul 15;15(14):3402-6. doi: 10.1016/j.bmcl.2005.05.021.
A novel series of imidazo[4,5-c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1.
已开发出一系列带有1,2,5-恶二唑-3-基胺官能团的新型咪唑并[4,5-c]吡啶。这些是有丝分裂原和应激激活蛋白激酶-1的强效抑制剂。
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