Tanaka T
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Toxicol Lett. 1992 May;60(3):315-24. doi: 10.1016/0378-4274(92)90290-z.
The color additive, amaranth, was given in the diet to provide dietary levels of 0 (control), 0.03, 0.09 and 0.27%, from 5 weeks of age in F0 generation mice to 9 weeks of age in F1 generation mice, and some reproductive, developmental and behavioral parameters were measured. There was no effect on the parameters of litters, litter size, pup weight and litter weight. The body weight of pups during the lactation period in the treatment groups increased less significantly, and the survival index at postnatal day (PND) 21 of the amaranth 0.27% group was reduced. Developmental parameters, direction of swimming on PND 4 in male pups and olfactory orientation in each sex were significantly reduced in the treatment groups. The dose levels of amaranth in this study influenced some reproductive, developmental and behavioral parameters in mice.
在饮食中添加食用色素苋菜红，从F0代小鼠5周龄到F1代小鼠9周龄，提供0（对照）、0.03%、0.09%和0.27%的膳食水平，并测量了一些生殖、发育和行为参数。对窝产仔数、窝仔大小、幼仔体重和窝仔体重参数没有影响。治疗组哺乳期幼仔的体重增加不太显著，苋菜红0.27%组出生后第21天（PND 21）的存活指数降低。治疗组雄性幼仔出生后第4天的游泳方向和各性别嗅觉定向等发育参数显著降低。本研究中苋菜红的剂量水平影响了小鼠的一些生殖、发育和行为参数。
