Tanaka T
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Food Chem Toxicol. 1993 Dec;31(12):1013-8. doi: 10.1016/0278-6915(93)90011-m.
The colour additive phloxine was given in the diet to provide dietary levels of 0 (control), 0.1, 0.3 and 0.9%, from 5 wk of age of the F0 generation to 8 wk of age of the F1 generation in mice, and selected reproductive and neurobehavioural parameters were measured. There was little effect of phloxine on either litter size or weight, or sex ratio, whereas the body weight of the pups in the lactation period was significantly increased in all treatment groups. Among the neurobehavioural parameters measured, surface righting at postnatal day 4 of male pups was significantly reduced in all treatment groups. Some parameters of the motor activity of pups at 3 wk of age differed from those of the controls; in particular, the average speed of movement male pups was significantly reduced in all treatment groups. The dose levels of phloxine in this study produced a few adverse effects in reproductive and neurobehavioural parameters in mice.
在小鼠的饮食中添加食用色素玫瑰红，从F0代5周龄到F1代8周龄，使饮食中的含量分别为0（对照）、0.1%、0.3%和0.9%，并测量选定的生殖和神经行为参数。玫瑰红对窝仔数、窝仔体重或性别比例几乎没有影响，而所有处理组哺乳期幼崽的体重均显著增加。在所测量的神经行为参数中，所有处理组雄性幼崽出生后第4天的表面翻正反射均显著降低。3周龄幼崽的一些运动活动参数与对照组不同；特别是，所有处理组雄性幼崽的平均移动速度均显著降低。本研究中玫瑰红的剂量水平对小鼠的生殖和神经行为参数产生了一些不良影响。
