Tanaka T
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Toxicology. 1994 Sep 6;92(1-3):169-77. doi: 10.1016/0300-483x(94)90175-9.
The color additive, Allura Red AC, was given in the diet to provide levels of 0.42, 0.84, and 1.68% (control, 0%), from 5 weeks of age of the F0 generation to 9 weeks of age of the F1 generation in mice, and selected reproductive and neurobehavioral parameters were measured. There were few adverse effects of Allura Red AC on either litter size or weight, and ratio of male to female was significantly reduced in the lowest dosed group. Average body weight of offspring during the lactation period was significantly increased in the lower dosed groups of each sex. As regards the neurobehavioral parameters, no adverse effect was observed in the behavioral development during lactation period. There were few adverse effects of Allura Red AC on either movement activity or maze learning in F1 generation mice, compared with controls in each sex. The dose levels of Allura Red AC in the present study (approximately 86-1430 times greater than human ADI) produced few adverse effects in reproductive and neurobehavioral parameters in mice.
在小鼠中，从F0代5周龄到F1代9周龄，在饮食中添加食用色素诱惑红AC，使其含量分别达到0.42%、0.84%和1.68%（对照组为0%），并测量了选定的生殖和神经行为参数。诱惑红AC对产仔数或体重几乎没有不良影响，在最低剂量组中，雄雌比例显著降低。各性别低剂量组的哺乳期后代平均体重显著增加。关于神经行为参数，在哺乳期的行为发育中未观察到不良影响。与各性别对照组相比，诱惑红AC对F1代小鼠的运动活动或迷宫学习几乎没有不良影响。本研究中诱惑红AC的剂量水平（约为人类每日允许摄入量的86 - 1430倍）对小鼠的生殖和神经行为参数几乎没有不良影响。
