Dickerson Tobin J, Kaufmann Gunnar F, Janda Kim D
Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Expert Opin Biol Ther. 2005 Jun;5(6):773-81. doi: 10.1517/14712598.5.6.773.
Cocaine addiction continues to be a major health and social problem in spite of governmental efforts devoted towards educating the public in the dangers of illicit drug use. A variety of pharmacotherapies and psychosocial programmes have been proposed in an effort to provide a method for alleviating the physical and psychological symptoms of cocaine abuse. Unfortunately, these methods have been met with limited success, illustrating a critical need for new effective approaches for the treatment of cocaine addiction. The authors have recently disclosed an alternative cocaine abuse treatment strategy using intranasal administration of an engineered filamentous bacteriophage displaying cocaine-sequestering antibodies on its surface. These phage particles are an effective vector for central nervous system penetration and are capable of binding cocaine, thereby blocking its behavioural effects in a rodent model.
尽管政府致力于向公众宣传非法药物使用的危害，但可卡因成瘾仍然是一个重大的健康和社会问题。为了提供一种缓解可卡因滥用的生理和心理症状的方法，人们提出了各种药物疗法和心理社会项目。不幸的是，这些方法取得的成功有限，这表明迫切需要新的有效方法来治疗可卡因成瘾。作者最近披露了一种替代的可卡因滥用治疗策略，即通过鼻内给药一种经过工程改造的丝状噬菌体，该噬菌体在其表面展示可卡因结合抗体。这些噬菌体颗粒是中枢神经系统渗透的有效载体，能够结合可卡因，从而在啮齿动物模型中阻断其行为效应。
