猪感染猪链球菌后血清转甲状腺素蛋白的负急性期反应
The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig.
作者信息
Campbell Fiona M, Waterston Mary, Andresen Lars Ole, Sorensen Nanna Skall, Heegaard Peter Mikael H, Eckersall P David
机构信息
Institute of Comparative Medicine, Division of Animal Production and Public Health, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, G61 1QH Glasgow, Scotland, UK.
出版信息
Vet Res. 2005 Jul-Aug;36(4):657-64. doi: 10.1051/vetres:2005017.
Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 microg/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 microg/mL (n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.
转甲状腺素蛋白（TTR）是一种血清蛋白，在人类中它是一种负急性期反应物，TTR的水平通常作为健康状况的指标进行测量。目前尚未为猪建立此类检测方法。为了在急性期反应期间测量猪血清中的TTR，开发了一种使用与猪TTR发生交叉反应的抗人TTR抗体的检测方法。该检测方法的检测限为32微克/毫升，而在健康猪血清中测得的转甲状腺素蛋白平均浓度为302±8微克/毫升（n = 63）。在10至25周的三个不同年龄组中，TTR的血清浓度没有显著差异。感染2型猪链球菌后，转甲状腺素蛋白表现出负急性期反应，感染后两天血清浓度显著降低。
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