溶组织内阿米巴核糖核酸酶III和AGO2（两种RNA干扰标志性蛋白）的分子特征分析
Molecular characterization of Entamoeba histolytica RNase III and AGO2, two RNA interference hallmark proteins.
作者信息
Abed Mona, Ankri Serge
机构信息
Department of Molecular Microbiology, The Bruce, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, POB 9649, Haifa 31096, Israel.
出版信息
Exp Parasitol. 2005 Jul;110(3):265-9. doi: 10.1016/j.exppara.2005.02.023. Epub 2005 Apr 7.
Entamoeba histolytica, a protozoan parasite with variable DNA content and complex ploidity, has defied most efforts aimed at gene depletion using classical genetic methods. In this study, we identified and characterized two proteins involved in the RNA interference (RNAi) pathway, RNase III and AGO2. Our results strengthen the findings that an RNAi pathway does exist in this parasite.
溶组织内阿米巴是一种具有可变DNA含量和复杂倍性的原生动物寄生虫，利用经典遗传方法进行基因敲减的大多数尝试都失败了。在本研究中，我们鉴定并表征了参与RNA干扰（RNAi）途径的两种蛋白质，即核糖核酸酶III和AGO2。我们的结果强化了该寄生虫中确实存在RNAi途径这一发现。
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