小沉默 RNA 在原生动物寄生虫中的新兴世界。
The emerging world of small silencing RNAs in protozoan parasites.
机构信息
Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06536, USA.
出版信息
Trends Parasitol. 2011 Jul;27(7):321-7. doi: 10.1016/j.pt.2011.03.002. Epub 2011 Apr 15.
Abstract
A new RNA world has emerged in the past 10 years with the discovery of a plethora of 20- to 30-nucleotide long small RNAs that are involved in various gene silencing mechanisms. These small RNAs have considerably changed our view of the regulation of gene expression in eukaryotic organisms, with a major shift towards epigenetic and post-transcriptional mechanisms. In this article, we focus on the striking diversity of small silencing RNAs that have been identified in several protozoan parasites and their potential biological role.
摘要
在过去的 10 年中，随着发现了大量参与各种基因沉默机制的 20 到 30 个核苷酸长的小 RNA，一个新的 RNA 世界已经出现。这些小 RNA 极大地改变了我们对真核生物基因表达调控的看法，主要转向了表观遗传和转录后机制。在本文中，我们专注于在几种原生动物寄生虫中已鉴定出的具有显著多样性的小沉默 RNA 及其潜在的生物学作用。
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