Fabian Dusan, Koppel Juraj, Maddox-Hyttel Poul
Institute of Animal Physiology, Slovak Academy of Sciences, Soltésovej 4, 04001 Kosice, Slovakia.
Theriogenology. 2005 Jul 15;64(2):221-31. doi: 10.1016/j.theriogenology.2004.11.022. Epub 2005 Jan 1.
The paper provides a review of the current state of knowledge on apoptosis during normal preimplantation development based on the literature and on the authors' own findings. Information is focused on the occurrence and the characteristics of spontaneous apoptotic processes. Reports concerning the chronology and the incidence of programmed cell death in mouse, cow, pig and human embryos in early preimplantation stages up to the blastocyst stage are summarized. In addition, specific attributes of the apoptotic process in mammalian preimplantation development are provided, including the description of both morphological and biochemical features of cell death.
本文基于文献及作者自身的研究结果，对正常植入前发育过程中细胞凋亡的当前知识状况进行了综述。信息聚焦于自发凋亡过程的发生情况及特征。总结了有关小鼠、牛、猪和人类胚胎在植入前早期直至囊胚阶段程序性细胞死亡的时间顺序和发生率的报告。此外，还介绍了哺乳动物植入前发育过程中凋亡过程的具体特征，包括细胞死亡的形态学和生化特征描述。
