Gorogawa Shin-Ichi, Kaneto Hideaki, Matsuhisa Munehide, Ohtoshi Kentaro, Kawamori Dan, Hazama Yoji, Yoshiuchi Kazutomi, Yamasaki Yoshimitsu
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Diabetes Res Clin Pract. 2005 Jul;69(1):1-4. doi: 10.1016/j.diabres.2004.10.006. Epub 2004 Dec 8.
The hallmark of type 2 diabetes is insulin resistance and insufficient insulin secretion, and appropriate therapy should be selected for each patient. In this study, to establish some index to select suitable therapy for each patient, we evaluated insulin sensitivity and insulin secretion with euglycemic hyperinsulinemic clamp and hyperglycemic clamp tests, respectively, and found that specific GIR index (GIRxIRI (90)) could be a useful marker to select suitable therapy for each type 2 diabetic patient (GIR: glucose infusion rate in euglycemic hyperinsulinemic clamp test; IRI (90): plasma insulin level 90 min after starting the hyperglycemic clamp test).
2型糖尿病的标志是胰岛素抵抗和胰岛素分泌不足，应针对每位患者选择合适的治疗方法。在本研究中，为建立一些指标以针对每位患者选择合适的治疗方法，我们分别通过正常血糖高胰岛素钳夹试验和高血糖钳夹试验评估胰岛素敏感性和胰岛素分泌，发现特定的葡萄糖输注率指数（GIRxIRI(90)）可能是为每位2型糖尿病患者选择合适治疗方法的有用标志物（GIR：正常血糖高胰岛素钳夹试验中的葡萄糖输注率；IRI(90)：高血糖钳夹试验开始90分钟后的血浆胰岛素水平）。
