Rufer Nathalie
Swiss Institute for Experimental Cancer Research (ISREC), NCCR Molecular Oncology, 155 ch. des Boveresses, CH-1066 Epalinges, Switzerland.
Curr Opin Immunol. 2005 Aug;17(4):441-7. doi: 10.1016/j.coi.2005.06.003.
Despite extended international efforts, the mechanisms governing T-cell receptor repertoire selection and kinetics in response to foreign or tumour antigens remain poorly characterized. A central goal of current research is to develop improved, reliable, immunological monitoring methods that measure and combine such parameters as the frequency of antigen-specific T cells and their functional capacities, as well as their clonal expansion during immune responses. Detecting and tracking defined anti-viral- and anti-tumour-specific T-cell responses ex vivo should lead to improvements in therapeutic strategies against viral infection or cancer in the future. During the past few years, highly sensitive tools have been developed to enable the molecular dissection and tracking of clonal T-cell expansion in animal models as well as in humans.
尽管国际上付出了诸多努力，但针对外来或肿瘤抗原的T细胞受体库选择及动力学的调控机制仍未得到充分阐明。当前研究的一个核心目标是开发出更完善、可靠的免疫监测方法，以测量并整合诸如抗原特异性T细胞的频率及其功能能力，以及它们在免疫反应期间的克隆性扩增等参数。在体外检测和追踪特定的抗病毒和抗肿瘤特异性T细胞反应，有望在未来改进针对病毒感染或癌症的治疗策略。在过去几年中，已经开发出了高灵敏度的工具，能够在动物模型以及人类中对克隆性T细胞扩增进行分子层面的剖析和追踪。
