Klenerman Paul, Cerundolo Vincenzo, Dunbar P Rod
Nuffield Department of Medicine, University of Oxford, UK.
Nat Rev Immunol. 2002 Apr;2(4):263-72. doi: 10.1038/nri777.
To understand the success or failure of immune responses against pathogens or tumours requires the direct measurement of specific lymphocytes. Recently, there has been an explosion of data in this field through the use of several new tools for measuring the number and function of T cells. This has allowed immunologists who study human disease and mouse models of infection and cancer to readily track specific T cells--in both time and space. Although there are common patterns, over time, each host-pathogen relationship seems to develop unique characteristics, as reflected in the quality of the T-cell response.
要了解针对病原体或肿瘤的免疫反应的成败，需要直接测量特定的淋巴细胞。最近，通过使用几种测量T细胞数量和功能的新工具，该领域的数据呈爆炸式增长。这使得研究人类疾病以及感染和癌症小鼠模型的免疫学家能够在时间和空间上轻松追踪特定的T细胞。尽管存在共同模式，但随着时间的推移，每种宿主与病原体的关系似乎都会发展出独特的特征，这在T细胞反应的质量中得到体现。
