Schwartz J G, Phillips W T, Langer O
Department of Pathology, University of Texas Health Science Center, San Antonio 78284-7750.
Am J Clin Pathol. 1992 Jun;97(6):831-5. doi: 10.1093/ajcp/97.6.831.
A lower osmolar oral glucose solution (50 g glucose in 450 mL fluid, 0.62 mol/L) was administered in addition to the standard hyperosmolar oral glucose solution (100 g glucose in 300 mL fluid, 1.85 mol/L) for oral glucose tolerance testing 1 week apart to 102 pregnant women. The standard oral glucose solution creates delayed gastric emptying and is associated with frequent nausea and vomiting. Results using the modified, lower osmolar glucose solution, when compared to the standard hyperosmolar glucose solution showed (1) statistically equivalent glucose excursion values 30 minutes after ingestion, (2) statistically significant decreased plasma glucose values greater than or equal to 60 minutes, (3) no statistically significant difference in insulin excursion values 30 minutes after ingestion, (4) equal area under the curve for glucose at 30 minutes using either solution, and (5) a markedly decreased incidence of nausea and vomiting. These data suggest that the modified, lower osmolar glucose solution empties rapidly from the stomach and allows the glucose to be absorbed and enter the peripheral circulation in an expeditious manner.
除了标准高渗口服葡萄糖溶液（300毫升液体中含100克葡萄糖，1.85摩尔/升）外，还给102名孕妇服用了低渗口服葡萄糖溶液（450毫升液体中含50克葡萄糖，0.62摩尔/升），用于口服葡萄糖耐量试验，两次试验间隔1周。标准口服葡萄糖溶液会导致胃排空延迟，并常伴有恶心和呕吐。与标准高渗葡萄糖溶液相比，使用改良的低渗葡萄糖溶液的结果显示：（1）摄入后30分钟的葡萄糖波动值在统计学上相当；（2）摄入后60分钟及以上血浆葡萄糖值在统计学上显著降低；（3）摄入后30分钟胰岛素波动值无统计学显著差异；（4）两种溶液在30分钟时葡萄糖曲线下面积相等；（5）恶心和呕吐的发生率显著降低。这些数据表明，改良的低渗葡萄糖溶液能迅速从胃中排空，使葡萄糖得以快速吸收并进入外周循环。
