Schwartz J G, Phillips W T, Aghebat-Khairy B
Department of Pathology, University of Texas Health Science Center, San Antonio 78284.
Clin Chem. 1990 Jan;36(1):125-8.
Nausea and vomiting have been recurrent problems with the oral glucose tolerance tests (OGTT) used to diagnose diabetes. We believe the nausea is associated with delayed gastric emptying caused by the high osmolarity of the glucose solution. In our pilot study, both the "standard" 100-g glucose OGTT and our new modified (lower osmolar) glucose solution were evaluated. Considerably delayed gastric emptying (along with severe nausea) was consistently noted with the standard OGTT. No nausea and a much more rapid gastric emptying time were recorded when the modified glucose solution was administered. We were able to diagnose diabetes (by using Wilkerson's point system) when our modified OGTT was administered to type 2 diabetics. We plan to develop a more physiological, more reproducible, and better tolerated OGTT to diagnose diabetes more accurately in the general population.
恶心和呕吐一直是用于诊断糖尿病的口服葡萄糖耐量试验（OGTT）中反复出现的问题。我们认为恶心与葡萄糖溶液的高渗透压导致的胃排空延迟有关。在我们的初步研究中，对“标准”的100克葡萄糖OGTT和我们新改良的（低渗透压）葡萄糖溶液都进行了评估。标准OGTT始终出现胃排空明显延迟（以及严重恶心）的情况。当给予改良葡萄糖溶液时，未记录到恶心且胃排空时间快得多。当我们将改良的OGTT应用于2型糖尿病患者时，能够（通过使用威尔克森评分系统）诊断出糖尿病。我们计划开发一种更符合生理、更具可重复性且耐受性更好的OGTT，以便在普通人群中更准确地诊断糖尿病。
