Kaneko Kenichi, Okamoto Ryoichi, Nakano Ryuichi, Kawakami Sayoko, Inoue Matsuhisa
Department of Environmental Infectious Diseases, Graduate School of Medical Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan.
J Clin Microbiol. 2005 Jun;43(6):2955-8. doi: 10.1128/JCM.43.6.2955-2958.2005.
AmpC regulatory genes in 21 ceftazidime-resistant clinical isolates of Enterobacter cloacae (MICs of > or = 16 microg/ml) were characterized. All isolates exhibited AmpC overproduction due to AmpD mutation. Additionally, we found two AmpR mutants among the isolates. This is the first report of chromosomal ampR mutation in clinical isolates of E. cloacae.
对21株阴沟肠杆菌头孢他啶耐药临床分离株(最低抑菌浓度≥16μg/ml)的AmpC调控基因进行了特征分析。所有分离株均因AmpD突变而表现出AmpC过量产生。此外,我们在分离株中发现了两个AmpR突变体。这是阴沟肠杆菌临床分离株中染色体ampR突变的首次报道。