Kuster Bernhard, Schirle Markus, Mallick Parag, Aebersold Ruedi
Department of Analytical Sciences and Informatics, Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Nat Rev Mol Cell Biol. 2005 Jul;6(7):577-83. doi: 10.1038/nrm1683.
Technologies for genome-wide analyses typically undergo a transition from a discovery phase to a scoring phase. In the discovery phase, the genomic universe is explored and all pertinent data are noted. In the scoring phase, relevant entities are screened to reveal groups of genes that are associated with specific biological processes or conditions. In this article, we propose that the transition from a discovery to a scoring phase is also essential, feasible and imminent for proteomics.
全基因组分析技术通常会经历从发现阶段到评分阶段的转变。在发现阶段，要对整个基因组领域进行探索并记录所有相关数据。在评分阶段，要筛选相关实体以揭示与特定生物学过程或状况相关的基因群组。在本文中，我们提出，从发现阶段到评分阶段的转变对于蛋白质组学来说也是至关重要、可行且迫在眉睫的。
