Phillips David I W, Bennett Franklyn I, Wilks Rainford, Thame Minerva, Boyne Michael, Osmond Clive, Forrester Terrence E
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
Paediatr Perinat Epidemiol. 2005 Jul;19(4):294-302. doi: 10.1111/j.1365-3016.2005.00661.x.
We tested the hypothesis that women who are thin or have poor pregnancy weight gain have offspring with higher blood pressure and examined whether this link is mediated by increased secretion of cortisol. We studied a cohort of 388 children born in Kingston, Jamaica. From hospital records we obtained information about their mother's body mass index (BMI) and weight gain during pregnancy. At age 8.5 years we measured the children's fasting plasma cortisol concentrations and blood pressure and assessed their mother's anthropometry. There were no relationships between the mother's BMI or weight gain during pregnancy and offspring blood pressure. However, mothers with a greater subscapular to triceps skinfold thickness ratio (SSTR) had offspring with higher blood pressure (5.6 mmHg systolic and 3.7 mmHg diastolic increase per unit change in SSTR, P = 0.002 and P = 0.008 respectively). Fasting plasma cortisol concentrations correlated with the children's systolic (r = 0.33, P < 0.0001) and diastolic pressures (r = 0.12, P = 0.02) independently of age, gender, weight or socio-economic status and were also predicted by the mother's SSTR. These findings suggest that maternal truncal obesity rather than thinness is associated with raised blood pressure in the offspring, and that this link may be mediated by increased cortisol secretion.
体型消瘦或孕期体重增加不佳的女性所生育的后代血压较高，并研究了这种关联是否由皮质醇分泌增加所介导。我们对在牙买加金斯敦出生的388名儿童组成的队列进行了研究。从医院记录中，我们获取了有关其母亲的体重指数（BMI）和孕期体重增加情况的信息。在儿童8.5岁时，我们测量了他们的空腹血浆皮质醇浓度和血压，并评估了其母亲的人体测量学指标。母亲的BMI或孕期体重增加与后代血压之间没有关联。然而，肩胛下与肱三头肌皮褶厚度比值（SSTR）较高的母亲所生育的后代血压较高（SSTR每单位变化，收缩压升高5.6 mmHg，舒张压升高3.7 mmHg，P分别为0.002和0.008）。空腹血浆皮质醇浓度与儿童的收缩压（r = 0.33，P < 0.0001）和舒张压（r = 0.12，P = 0.02）相关，且独立于年龄、性别、体重或社会经济地位，同时也可由母亲的SSTR预测。这些发现表明，母亲腹部肥胖而非消瘦与后代血压升高有关，并且这种关联可能由皮质醇分泌增加所介导。
