母体肥胖对狒狒（狒狒属物种）胎儿期及出生后早期生命表型的影响。
Effect of maternal obesity on fetal and postnatal baboon (Papio species) early life phenotype.
作者信息
Li Cun, Jenkins Susan, Considine McKenna M, Cox Laura A, Gerow Kenneth G, Huber Hillary F, Nathanielsz Peter W
机构信息
Texas Pregnancy and Life-course Health Center, Department of Animal Sciences, University of Wyoming, Laramie, Wyoming.
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas.
出版信息
J Med Primatol. 2019 Apr;48(2):90-98. doi: 10.1111/jmp.12396. Epub 2018 Dec 20.
BACKGROUND
Non-human primate models of developmental programming by maternal obesity (MO) are needed for translation to human programming outcomes. We present baboon offspring (F1) morphometry, blood cortisol, and adrenocorticotropic hormone (ACTH) from 0.9 gestation to 0-2 years.
METHODS
Control mothers ate chow; MO mothers ate high-fat high-energy diet pre-pregnancy through lactation.
RESULTS
Maternal obesity mothers weighed more than controls pre-pregnancy. Maternal obesity gestational weight gain was lower with no correlation with fetal or placenta weights. At 0.9 gestation, MO and control F1 morphometry and ACTH were similar. MO-F1 0.9 gestation male cortisol was lower, rising slower from 0-2 years vs control-F1. At birth, male MO-F1 and control-F1 weights were similar, but growth from 0-2 years was steeper in MO-F1; newborn female MO-F1 weighed more than control-F1 but growth from 0-2 years was similar. ACTH did not change in either sex.
CONCLUSIONS
Maternal obesity produced sexually dimorphic fetal and postnatal growth and hormonal phenotypes.
背景
需要通过母体肥胖（MO）建立发育编程的非人灵长类动物模型，以便转化为人类编程结果。我们展示了狒狒后代（F1）从妊娠0.9期到0至2岁的形态测量、血液皮质醇和促肾上腺皮质激素（ACTH）情况。
方法
对照母亲食用普通食物；MO母亲在怀孕前至哺乳期食用高脂高能量饮食。
结果
肥胖母亲孕前体重高于对照组。肥胖母亲孕期体重增加较低，与胎儿或胎盘重量无关。在妊娠0.9期，MO和对照F1的形态测量和ACTH相似。MO-F1妊娠0.9期雄性皮质醇较低，从0至2岁上升速度比对照F1慢。出生时，雄性MO-F1和对照F1体重相似，但0至2岁时MO-F1的生长更陡峭；新生雌性MO-F1体重高于对照F1，但0至2岁时生长相似。两性的ACTH均无变化。
结论
母体肥胖产生了性别差异的胎儿期和出生后生长及激素表型。
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