Eschwège E
INSERM U258, Hôpital Paul-Brousse, F-94807 Villejuif Cedex, France.
Ann Endocrinol (Paris). 2005 Apr;66(2 Pt 2):1S32-44.
Several definitions are currently proposed to define metabolic syndrome (WHO, EGIR, NCEP-ATP III, AACE). The interest and the drawbacks of these definitions, as well as the "hypertriglyceridemic waist" phenotype proposed by Canadian authors, are described. All observational studies indicate an increased cardiovascular morbidity and mortality risk, and likely a type 2 diabetes increased risk, in individuals with metabolic syndrome. Therefore, it is justified to identify these individuals in order to implement preventive or therapeutic measures, and to be able to evaluate the intervention results. Use of any metabolic syndrome definition should be driven by the objective: either epidemiological studies, or clinical trials or assessment of intervention programs, or public health campaigns, or clinical management of at-risk individuals. The rationale for choosing one of these definitions is discussed on the basis of recent publications.
目前提出了几种定义来界定代谢综合征（世界卫生组织、欧洲胰岛素抵抗研究组、美国国家胆固醇教育计划成人治疗组第三次报告、美国临床内分泌医师协会）。文中描述了这些定义的优点和缺点，以及加拿大作者提出的“高甘油三酯腰围”表型。所有观察性研究均表明，患有代谢综合征的个体心血管发病和死亡风险增加，2型糖尿病风险可能也会增加。因此，识别出这些个体以实施预防或治疗措施，并能够评估干预结果是合理的。任何代谢综合征定义的使用都应由目标驱动：要么是流行病学研究，要么是临床试验、干预项目评估、公共卫生运动，要么是高危个体的临床管理。基于近期的出版物，讨论了选择这些定义之一的基本原理。
