Jin L, Rima B, Brown D, Orvell C, Tecle T, Afzal M, Uchida K, Nakayama T, Song J-W, Kang C, Rota P A, Xu W, Featherstone D
Virus Reference Department, Centre for Infections, Health Protection Agency, London, UK.
Arch Virol. 2005 Sep;150(9):1903-9. doi: 10.1007/s00705-005-0563-4. Epub 2005 Jun 15.
Though mumps virus (MuV) is a monotypic virus, genetic variation between strains has been described. Viruses have been placed into genotypes designated A-L based on the nucleotide sequence of the small hydrophobic (SH) gene, which is the most variable gene in the mumps genome. Molecular characterisation of MuV is an important component of mumps surveillance because it can help identify the transmission pathways of the virus as well as distinguish between wild-type and vaccine strains. Here, we propose a standardized nomenclature and an analysis protocol for the genetic characterisation of mumps strains to facilitate expansion of molecular epidemiological studies. In addition to assigning standard reference strains for the recognized genotypes of MuV, a convention is proposed for naming for strains and criteria to designate a new genotype.
尽管腮腺炎病毒（MuV）是一种单型病毒，但已报道了不同毒株之间的基因变异。根据小疏水（SH）基因的核苷酸序列，病毒已被分为A-L基因型，SH基因是腮腺炎病毒基因组中变异最大的基因。MuV的分子特征分析是腮腺炎监测的重要组成部分，因为它有助于确定病毒的传播途径，并区分野生型和疫苗株。在此，我们提出一种标准化命名法和腮腺炎毒株基因特征分析方案，以促进分子流行病学研究的扩展。除了为已识别的MuV基因型指定标准参考毒株外，还提出了一种毒株命名惯例和指定新基因型的标准。
Zotero 插件