p53、DCC和HER-2/neu在乳腺黏液癌中的表达。
Expression of p53, DCC, and HER-2/neu in mucinous carcinoma of the breast.
作者信息
Hsu Yung-Hsiang, Shaw Cheng-Kuang
机构信息
Department of Pathology, Buddhist Tzu Chi General Hospital and University, Hualien, Taiwan.
出版信息
Kaohsiung J Med Sci. 2005 May;21(5):197-202. doi: 10.1016/S1607-551X(09)70188-3.
We investigated the clinicopathologic and oncoprotein expression characteristics of 11 pure mucinous and 76 non-mucinous infiltrating ductal carcinomas in the human female breast. We compared patient age, tumor size, axillary lymph node status, and the expression of estrogen receptor (ER), progesterone receptor (PR), deleted-in-colon cancer (DCC), HER-2/neu, and p53. Mucinous carcinoma with axillary lymph node metastasis occurs less frequently than non-mucinous carcinoma (0% vs 63.1%; p = 0.0018). Compared with the non-mucinous type, mucinous carcinoma specimens have more DCC expression (100% vs 48.7%; p = 0.0027) and more ER expression (90.9% vs 26.9%; p = 0.0023), but less HER-2/neu overexpression (0% vs 38.1%; p = 0.0302). We confirmed that mucinous carcinoma samples from the breast reveal distinct clinicopathologic and oncoprotein expression features compared with non-mucinous carcinoma and, therefore, it seems reasonable to suggest different biologic characteristics and manifestations.
我们研究了11例纯黏液性和76例非黏液性浸润性导管癌在女性乳腺中的临床病理及癌蛋白表达特征。我们比较了患者年龄、肿瘤大小、腋窝淋巴结状态以及雌激素受体（ER）、孕激素受体（PR）、结肠癌缺失基因（DCC）、HER-2/neu和p53的表达情况。伴有腋窝淋巴结转移的黏液性癌发生率低于非黏液性癌（0%对63.1%；p = 0.0018）。与非黏液性类型相比，黏液性癌标本中DCC表达更多（100%对48.7%；p = 0.0027），ER表达更多（90.9%对26.9%；p = 0.0023），但HER-2/neu过表达更少（0%对38.1%；p = 0.0302）。我们证实，与非黏液性癌相比，乳腺黏液性癌标本具有独特的临床病理及癌蛋白表达特征，因此，提示其具有不同的生物学特性和表现似乎是合理的。
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