Cho Li-Chen, Hsu Yung-Hsiang
Department of Nursing, Tzu Chi College of Technology, Buddhist Tzu Chi General Hospital and University, Hualien, Taiwan.
Kaohsiung J Med Sci. 2008 May;24(5):227-32. doi: 10.1016/S1607-551X(08)70146-3.
Hormone receptors play important roles in breast cancer. We investigated the expression of hormone receptors in breast cancer to evaluate the importance of hormone receptors in the clinicopathology of breast cancer. Androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR) expression characteristics were evaluated using immunohistochemistry stain, comparing patient age, tumor size and axillary lymph node status for 23 pure mucinous and 105 non-mucinous infiltrating ductal carcinomas in the human female breast. Mucinous carcinoma with axillary lymph node metastasis occurred less frequently than non-mucinous carcinoma (11.8% vs. 55.2%; p = 0.01). Compared with the non-mucinous type, mucinous carcinoma specimens showed less AR expression (21.7% vs. 51.4%; p = 0.01) but more ER expression (78.3% vs. 52.4%; p = 0.02). In addition, AR expression was also associated with ER and/or PR coexpression (37/74, 50%) in infiltrating ductal carcinoma. But only three of 20 (15%) mucinous carcinoma specimens with AR expression had associated ER and/or PR coexpression. Our findings revealed that mucinous carcinoma samples from the breast show distinct clinicopathologic and hormone receptor expression features compared to non-mucinous carcinoma.
激素受体在乳腺癌中发挥着重要作用。我们研究了乳腺癌中激素受体的表达，以评估激素受体在乳腺癌临床病理学中的重要性。使用免疫组织化学染色评估雄激素受体（AR）、雌激素受体（ER）和孕激素受体（PR）的表达特征，比较了23例纯黏液性和105例非黏液性浸润性导管癌患者的年龄、肿瘤大小和腋窝淋巴结状态。黏液性癌伴腋窝淋巴结转移的发生率低于非黏液性癌（11.8%对55.2%；p = 0.01）。与非黏液性类型相比，黏液性癌标本显示AR表达较少（21.7%对51.4%；p = 0.01），但ER表达较多（78.3%对52.4%；p = 0.02）。此外，在浸润性导管癌中，AR表达也与ER和/或PR共表达相关（37/74，50%）。但在20例（15%）有AR表达的黏液性癌标本中，只有3例有相关的ER和/或PR共表达。我们的研究结果表明，与非黏液性癌相比，来自乳腺的黏液性癌标本表现出独特的临床病理和激素受体表达特征。
