单纯黏液性乳腺癌：一种有利的亚型。
Pure mucinous breast carcinoma: a favorable subtype.
机构信息
Department of Breast Surgery, Breast Tumor Center, China-Japan Friendship Hospital, Beijing, China.
Institute of Clinical Science, China-Japan Friendship Hospital, Beijing, China.
出版信息
Breast Care (Basel). 2013 Mar;8(1):56-9. doi: 10.1159/000346828.
BACKGROUND
Pure mucinous breast carcinoma is a relatively rare subtype of breast malignancy. This study is to investigate the clinical and pathologic features of pure mucinous breast carcinoma.
PATIENTS AND METHODS
A retrospective review of our database of patients who presented with breast cancer was performed. The medical records of 1,060 patients with invasive breast cancer who underwent surgery were reviewed.
RESULTS
28 patients with pure mucinous breast cancer were identified. The mean age was 55.28 ± 15.73 years. 17 patients underwent modified radical mastectomy; 11 underwent breast-conserving therapy. The tumor size was T1 in 19 patients, T2 in 8 patients, and T3 in 1 patient. None of the patients had lymph node metastasis. There was no distant metastasis. 18 were stage I, and 10 were stage II. Estrogen receptor, progesterone receptor, HER-2, and P53 were positive in 96, 93, 0, and 28%, respectively. Median follow-up was 42 months (range 1-84 months). 1 patient had local recurrence. The overall survival rate was 100%.
CONCLUSION
Pure mucinous breast carcinoma has a favorable prognosis. Less invasive treatment might be optional. Larger data samples with longer follow-up would be necessary to gain a better understanding of this disease.
背景
单纯黏液性乳腺癌是一种较为罕见的乳腺恶性肿瘤亚型。本研究旨在探讨单纯黏液性乳腺癌的临床和病理特征。
患者与方法
我们对就诊于我院的乳腺癌患者数据库进行了回顾性研究。共对 1060 例行手术治疗的浸润性乳腺癌患者的病历进行了回顾。
结果
共发现 28 例单纯黏液性乳腺癌患者。患者平均年龄为 55.28±15.73 岁。17 例行改良根治术，11 例行保乳治疗。肿瘤大小 T1 期 19 例，T2 期 8 例，T3 期 1 例。所有患者均无淋巴结转移，无远处转移。Ⅰ期 18 例，Ⅱ期 10 例。96%的患者雌激素受体、孕激素受体、HER-2 及 P53 阳性，分别为 93%、0、28%。中位随访时间为 42 个月（1-84 个月）。1 例患者局部复发。总生存率为 100%。
结论
单纯黏液性乳腺癌预后良好，选择侵袭性较小的治疗方法可能是合理的。需要更大的样本量和更长的随访时间来更好地了解这种疾病。
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