Bilwani Fareena, Adil Salman N, Sheikh Usman, Humera Ayesha, Khurshid Mohammad
Department of Pathology, The Aga Khan University Hospital, Karachi.
J Pak Med Assoc. 2005 May;55(5):217-9.
We report a case of anaphylactic reaction to intramuscular injection of cyanocobalamin. This 52-year-old lady was diagnosed as a case of megaloblastic anemia secondary to dietary vitamin B12 deficiency. She had severe anaphylactic reaction after the parenteral administration of cyanocobalamine. Later she received oral vitamin B12 with no adverse effects. The purpose of this case report is to draw attention to the hypersensitive reaction to injectable vitamin B12, which is rarely seen. This could be due to sensitization to the vitamin B12 molecule itself or an IgE mediated reaction. We concluded that anaphylactic reaction to vitamin B12 is a rare but serious side effect and it should be kept in mind while the drug is being administered to the patient, especially via the parenteral route.
我们报告一例肌肉注射钴胺素引起过敏反应的病例。这位52岁的女性被诊断为继发于饮食中维生素B12缺乏的巨幼细胞贫血。她在胃肠外给予钴胺素后发生了严重的过敏反应。后来她口服维生素B12，未出现不良反应。本病例报告的目的是提醒注意对注射用维生素B12的过敏反应，这种情况很少见。这可能是由于对维生素B12分子本身致敏或IgE介导的反应。我们得出结论，维生素B12过敏反应是一种罕见但严重的副作用，在给患者使用该药物时，尤其是通过胃肠外途径给药时，应予以注意。
