Ordeix Laura, Solano-Gallego Laia, Fondevila Dolors, Ferrer Lluis, Fondati Alessandra
Departament de Medicina i Cirurgia Animal, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Barcelona, Spain.
Vet Dermatol. 2005 Jun;16(3):187-91. doi: 10.1111/j.1365-3164.2005.00454.x.
Papular dermatitis due to Leishmania spp. infection was diagnosed in three boxers and two Rottweilers with Leishmania-specific cellular immunity. Diagnosis was based on histological and immunohistochemical examination of papules in four dogs and on cytological examination in one dog. Serum protein electrophoresis was within reference ranges and low antibody levels to Leishmania infantum were detected. Delayed-type hypersensitivity (DTH) reaction to leishmanin was evaluated before treatment in three dogs with positive results. After meglumine antimoniate therapy for 3 to 4 weeks and allopurinol treatment for 6 to 10 months, all dogs were clinically normal, had positive DTH reactions to leishmanin and reduced antibody titres. In conclusion, we suggest that this previously unreported cutaneous presentation of canine leishmaniosis appears to be associated with specific immunocompetence and, consequently, with a favourable prognosis.
在三只拳师犬和两只罗威纳犬中诊断出由利什曼原虫属感染引起的丘疹性皮炎，这些犬具有利什曼原虫特异性细胞免疫。诊断基于对四只犬丘疹的组织学和免疫组织化学检查以及对一只犬的细胞学检查。血清蛋白电泳在参考范围内，检测到针对婴儿利什曼原虫的低抗体水平。在三只犬治疗前评估了对利什曼原虫素的迟发型超敏反应（DTH），结果呈阳性。在用葡甲胺锑酸盐治疗3至4周和别嘌呤醇治疗6至10个月后，所有犬临床正常，对利什曼原虫素的DTH反应呈阳性且抗体滴度降低。总之，我们认为这种先前未报道的犬利什曼病皮肤表现似乎与特定的免疫能力相关，因此预后良好。
