促肾上腺皮质激素释放激素诱导幼鼠癫痫发作起源于杏仁核。
Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala.
作者信息
Baram T Z, Hirsch E, Snead O C, Schultz L
机构信息
Department of Neurology, University of Southern California, Los Angeles.
出版信息
Ann Neurol. 1992 May;31(5):488-94. doi: 10.1002/ana.410310505.
Abstract
The neuroanatomical substrate of seizures induced by picomolar amounts of corticotropin-releasing hormone in infant rats was investigated. Electrographic and behavioral phenomena were monitored in 42 rat pups aged 5 to 22 days. Rat pups carried bipolar electrodes implanted in subcortical limbic structures, as well as cortical electrodes and intracerebroventricular cannulae. The administration of corticotropin-releasing hormone produced age-specific seizures within minutes, which correlated with rhythmic amygdala discharges. Paroxysmal hippocampal and cortical discharges developed subsequently in some rats. Corticotropin-releasing hormone-induced electrographic and behavioral seizures originate in the amygdala.
摘要
研究了皮摩尔量促肾上腺皮质激素释放激素诱导幼鼠癫痫发作的神经解剖学基础。对42只5至22日龄的幼鼠进行了脑电图和行为现象监测。幼鼠植入了位于皮质下边缘结构的双极电极、皮质电极和脑室内插管。促肾上腺皮质激素释放激素给药后几分钟内就产生了年龄特异性癫痫发作，这与杏仁核的节律性放电相关。随后，一些大鼠出现了阵发性海马和皮质放电。促肾上腺皮质激素释放激素诱导的脑电图和行为性癫痫发作起源于杏仁核。
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