Bayesian neural network approaches to ovarian cancer identification from high-resolution mass spectrometry data.

MOTIVATION

The classification of high-dimensional data is always a challenge to statistical machine learning. We propose a novel method named shallow feature selection that assigns each feature a probability of being selected based on the structure of training data itself. Independent of particular classifiers, the high dimension of biodata can be fleetly reduced to an applicable case for consequential processing. Moreover, to improve both efficiency and performance of classification, these prior probabilities are further used to specify the distributions of top-level hyperparameters in hierarchical models of Bayesian neural network (BNN), as well as the parameters in Gaussian process models.

RESULTS

Three BNN approaches were derived and then applied to identify ovarian cancer from NCI's high-resolution mass spectrometry data, which yielded an excellent performance in 1000 independent k-fold cross validations (k = 2,...,10). For instance, indices of average sensitivity and specificity of 98.56 and 98.42%, respectively, were achieved in the 2-fold cross validations. Furthermore, only one control and one cancer were misclassified in the leave-one-out cross validation. Some other popular classifiers were also tested for comparison.

AVAILABILITY

The programs implemented in MatLab, R and Neal's fbm.2004-11-10.