Domingos Pedro M, Steller Hermann
Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
Curr Opin Genet Dev. 2007 Aug;17(4):294-9. doi: 10.1016/j.gde.2007.05.009. Epub 2007 Jul 12.
The patterning and development of multicellular organisms require a precisely controlled balance between cell proliferation, differentiation and death. The regulation of apoptosis is an important aspect to achieve this balance, by eliminating unnecessary or mis-specified cells which, otherwise, may have harmful effects on the whole organism. Apoptosis is also important for the morphogenetic processes that occur during development and that lead to the sculpting of organs and other body structures. Here, we review recent progress in understanding how apoptosis is regulated during development, focusing on studies using Drosophila or Caenorhabditis elegans as model organisms.
多细胞生物的模式形成和发育需要在细胞增殖、分化和死亡之间精确控制平衡。细胞凋亡的调控是实现这种平衡的一个重要方面，它通过消除不必要的或指定错误的细胞来实现，否则这些细胞可能会对整个生物体产生有害影响。细胞凋亡对于发育过程中发生的形态发生过程也很重要，这些过程导致器官和其他身体结构的塑造。在这里，我们回顾了在理解发育过程中细胞凋亡如何被调控方面的最新进展，重点关注以果蝇或秀丽隐杆线虫为模式生物的研究。
