Lindner Axel, Thier Peter, Kircher Tilo T J, Haarmeier Thomas, Leube Dirk T
Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, Hoppe-Seyler-Str. 3, D72076 Tübingen, Germany.
Curr Biol. 2005 Jun 21;15(12):1119-24. doi: 10.1016/j.cub.2005.05.049.
Psychopathological symptoms in schizophrenia patients suggest that the concept of self might be disturbed in these individuals [1]. Delusions of influence make them feel that someone else is guiding their actions, and certain kinds of their hallucinations seem to be misinterpretations of their own inner voice as an external voice, the common denominator being that self-produced information is perceived as if coming from outside. If this interpretation were correct, we might expect that schizophrenia patients might also attribute the sensory consequences of their own eye movements to the environment rather than to themselves, challenging the percept of a stable world. Indeed, this seems to be the case because we found a clear correlation between the strength of delusions of influence and the ability of schizophrenia patients to cancel out such self-induced retinal information in motion perception. This correlation reflects direct experimental evidence supporting the view that delusions of influence in schizophrenia might be due to a specific deficit in the perceptual compensation of the sensory consequences of one's own actions [1, 2, 3, 4, 5 and 6].
精神分裂症患者的精神病理症状表明，这些个体的自我概念可能受到了干扰[1]。被控制妄想让他们觉得是别人在指导自己的行动，而他们的某些幻觉似乎是将自己内心的声音错误地解读为外部声音，其共同点在于，自我产生的信息被感知为仿佛来自外部。如果这种解释是正确的，我们可能会预期精神分裂症患者也会将自己眼球运动的感觉后果归因于环境而非自身，这对稳定世界的感知提出了挑战。事实上，情况似乎就是如此，因为我们发现被控制妄想的严重程度与精神分裂症患者在运动感知中抵消这种自我诱发的视网膜信息的能力之间存在明显的相关性。这种相关性反映了直接的实验证据，支持了这样一种观点，即精神分裂症中的被控制妄想可能是由于个体自身行动的感觉后果在感知补偿方面存在特定缺陷所致[1, 2, 3, 4, 5和6]。
