Hillebrand Jacquelien J G, Kas Martien J H, Adan Roger A H
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3594 CG Utrecht, The Netherlands.
Peptides. 2005 Oct;26(10):1690-6. doi: 10.1016/j.peptides.2004.11.027.
Activity-based anorexia (ABA) is considered an animal model of anorexia nervosa (AN). In ABA, scheduled feeding in combination with voluntary access to running wheels, results in hyperactivity, hypophagia, body weight loss and activation of the HPA axis. Since stimulation of the melanocortin (MC) system has similar effects, this system is a candidate system involved in ABA. Here it is shown that chronic alpha-MSH treatment enhances ABA by increasing running wheel activity (RWA), decreasing food intake and increasing HPA axis activation.
基于活动的厌食症（ABA）被认为是神经性厌食症（AN）的动物模型。在ABA中，定时喂食与自愿使用跑步轮相结合，会导致多动、食欲减退、体重减轻以及下丘脑-垂体-肾上腺（HPA）轴的激活。由于刺激黑皮质素（MC）系统有类似的效果，该系统是参与ABA的一个候选系统。本文表明，慢性α-促黑素（α-MSH）治疗通过增加跑步轮活动（RWA）、减少食物摄入和增加HPA轴激活来增强ABA。
