血清药理学在中药中的应用初步研究。
Primary study on the application of Serum Pharmacology in Chinese traditional medicine.
作者信息
Bochu Wang, Liancai Zhu, Qi Chen
机构信息
Key Laboratory for Biomechanics & Tissue Engineering under the State Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, PR China.
出版信息
Colloids Surf B Biointerfaces. 2005 Jul 10;43(3-4):194-7. doi: 10.1016/j.colsurfb.2005.04.013.
In the paper, two main methods, which are Serum Pharmacology and Traditional Pharmacology, were adopted to study Chinese traditional medicine, such as Ginkgo biloba extract (GBE), ginsenosides (GS) and compound GG (GBE+GS), pharmacology in vitro. The results showed that there were evident difference between the results of Serum Pharmacology and that of Traditional Pharmacology. There was no significant difference between the drug effect of crude GS on nitric oxide (NO) production in ECV304 and that of crude GBE, and the drug effect of GG was superior to that of GS and GBE, respectively. But, compared with GBE serum, the GS serum up-regulation of NO production in ECV304 increased significantly, and the GG serum up-regulation of the NO production in ECV304 was inferior to that of GS serum and GBE serum significantly. The results suggested that Serum Pharmacological study should be adopted in the pharmacological investigation on the Chinese traditional medicine and the drug screening of the Chinese traditional medicine.
在该论文中，采用血清药理学和传统药理学这两种主要方法对银杏叶提取物（GBE）、人参皂苷（GS）和复方GG（GBE+GS）等中药进行体外药理学研究。结果表明，血清药理学结果与传统药理学结果之间存在明显差异。粗GS对ECV304细胞一氧化氮（NO）生成的药物作用与粗GBE的药物作用无显著差异，且GG的药物作用分别优于GS和GBE。但是，与GBE血清相比，GS血清使ECV304细胞中NO生成的上调显著增加，而GG血清使ECV304细胞中NO生成的上调显著低于GS血清和GBE血清。结果提示，在中药药理学研究和中药药物筛选中应采用血清药理学研究。
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