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升仙汤治疗人肺腺癌疗效的化学与生物学证据

Chemical and Biological Evidence of the Efficacy of Shengxian Decoction for Treating Human Lung Adenocarcinoma.

作者信息

Li Kejuan, You Fengming, Zhang Qin, Yuan Ruijiao, Yuan Qianghua, Fu Xi, Ren Yifeng, Wang Qian, Li Xiaohong, Zhang Zhenya, Shichiri Mototada, Yu Yue

机构信息

College of Life Science, Sichuan Normal University, Chengdu, China.

Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.

出版信息

Front Oncol. 2022 Mar 18;12:849579. doi: 10.3389/fonc.2022.849579. eCollection 2022.

DOI:10.3389/fonc.2022.849579
PMID:35372052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8975620/
Abstract

Shengxian Decoction (SXT) is a traditional Chinese medicine prescription comprising several anti-cancer medicinal herbs. However, the anti-cancer effect of SXT has rarely been reported. Herein, we explored the therapeutic potential of SXT for the treatment of lung adenocarcinoma (LUAD). High-performance liquid chromatography analysis of crude SXT extract revealed the abundance of mangiferin, an established anti-cancer compound. The serum pharmacological evaluation revealed that serum SXT suppressed A549 lung cancer cell proliferation . The tumor-inhibitory activity of SXT was confirmed tumor formation assays in nude mice. We applied biochemical, histopathological and imaging approaches to investigate the cellular targets of SXT. The results indicated that the treatment with SXT induced tumor necrosis, and downregulated hypoxia-inducible factor 1 alpha in the serum. biosafety assessment of SXT revealed low levels of toxicity in mouse models. Our study provides the first scientific evidence that SXT effectively represses cancer cell growth and, thus, may serve as a safe anti-cancer agent for LUAD treatment.

摘要

升仙汤（SXT）是一种由多种抗癌草药组成的中药方剂。然而，SXT的抗癌作用鲜有报道。在此，我们探讨了SXT治疗肺腺癌（LUAD）的潜在疗效。对SXT粗提物进行高效液相色谱分析，发现其中富含已确定的抗癌化合物芒果苷。血清药理学评价显示，含药血清SXT可抑制A549肺癌细胞增殖。通过裸鼠肿瘤形成实验证实了SXT的肿瘤抑制活性。我们应用生化、组织病理学和影像学方法研究SXT的细胞靶点。结果表明，SXT治疗可诱导肿瘤坏死，并下调血清中缺氧诱导因子1α的表达。SXT的生物安全性评估显示，在小鼠模型中其毒性较低。我们的研究提供了首个科学证据，表明SXT可有效抑制癌细胞生长，因此可能作为一种安全的抗癌药物用于LUAD的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c65/8975620/f7c1c828e120/fonc-12-849579-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c65/8975620/0128672ebd8e/fonc-12-849579-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c65/8975620/ffcf8c96237b/fonc-12-849579-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c65/8975620/b13a2e431d5c/fonc-12-849579-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c65/8975620/f7c1c828e120/fonc-12-849579-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c65/8975620/0128672ebd8e/fonc-12-849579-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c65/8975620/16796ac94957/fonc-12-849579-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c65/8975620/ffcf8c96237b/fonc-12-849579-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c65/8975620/a4fa939daf8f/fonc-12-849579-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c65/8975620/b13a2e431d5c/fonc-12-849579-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c65/8975620/f7c1c828e120/fonc-12-849579-g006.jpg

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