Magariños-Ascone C M, Regidor I, Martínez-Castrillo J C, Gómez-Galán M, Figueiras-Méndez R
Neurología Experimental, Dipartimento di Investigación, Hospital Ramón y Cajal, Madrid 28034, Spain.
J Neurol Neurosurg Psychiatry. 2005 Jul;76(7):989-91. doi: 10.1136/jnnp.2004.039248.
A patient with myoclonus-dystonia syndrome was treated by implanting electrodes in the internal segment of the globus pallidus (GPi) and applying deep brain stimulation. Surgery was done in two sessions. The most affected limb was treated first and the other limb one year later. Neuronal recordings showed that most pallidal neurones discharged in bursts at a relatively low firing rate (mean (SD), 46 (18) Hz) compared with cells in the GPi in patients with Parkinson's disease. Neurones modified the rate and mode of discharge with dystonic postures and rapid involuntary contractions of limb muscles. Neurological examination at 24 months after surgery showed a decline of 47.8% and 78.5% in the Burke-Fahn-Marsden and disability rating scales, respectively.
一名患有肌阵挛性肌张力障碍综合征的患者通过在苍白球内侧部（GPi）植入电极并进行脑深部电刺激进行治疗。手术分两个阶段进行。首先治疗受影响最严重的肢体，另一个肢体在一年后治疗。神经元记录显示，与帕金森病患者的GPi细胞相比，大多数苍白球神经元以相对较低的放电频率（平均（标准差），46（18）Hz）成簇放电。神经元随着肌张力障碍姿势和肢体肌肉的快速不自主收缩而改变放电频率和模式。术后24个月的神经学检查显示，伯克-法恩-马斯登量表和残疾评定量表分别下降了47.8%和78.5%。
