Smg1无义突变不会消除果蝇中的无义介导的mRNA降解。
Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster.
作者信息
Chen Zhenzhong, Smith Katherine R, Batterham Philip, Robin Charles
机构信息
Centre for Environmental Stress and Adaptation Research, Department of Genetics, University of Melbourne, Melbourne, Victoria 3010, Australia.
出版信息
Genetics. 2005 Sep;171(1):403-6. doi: 10.1534/genetics.105.045674. Epub 2005 Jun 18.
Abstract
Smg1 is a key component of nonsense-mediated decay (NMD) in Caenorhabditis elegans and mammals. Here we report that two nonsense alleles of the ortholog of Smg1 do not affect NMD in Drosophila melanogaster.
摘要
Smg1是秀丽隐杆线虫和哺乳动物中无义介导的mRNA降解（NMD）的关键组成部分。在此我们报告，Smg1直系同源基因的两个无义等位基因并不影响黑腹果蝇中的NMD。
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2
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Curr Biol. 2002 Mar 19;12(6):R196-7. doi: 10.1016/s0960-9822(02)00747-9.
3
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Genes Dev. 2001 Nov 1;15(21):2781-5. doi: 10.1101/gad.943701.
4
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Genes Dev. 2001 Sep 1;15(17):2215-28. doi: 10.1101/gad.913001.
5
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6
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7
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