治疗期间癌细胞的再增殖：治疗失败的一个重要原因。
Repopulation of cancer cells during therapy: an important cause of treatment failure.
作者信息
Kim John J, Tannock Ian F
机构信息
Department of Radiation Oncology, Princess Margaret Hospital and University of Toronto, 610 University Avenue, Toronto, ON M5G 2M9, Canada.
出版信息
Nat Rev Cancer. 2005 Jul;5(7):516-25. doi: 10.1038/nrc1650.
Radiotherapy and chemotherapy are given in multiple doses, which are spaced out to allow the recovery of normal tissues between treatments. However, surviving cancer cells also proliferate during the intervals between treatments and this process of repopulation is an important cause of treatment failure. Strategies developed to overcome repopulation have improved clinical outcomes, and now new strategies to inhibit repopulation are emerging in parallel with advances in the understanding of underlying biological mechanisms.
放射治疗和化疗采用多剂量给药，各剂量之间有时间间隔，以便在治疗期间使正常组织得以恢复。然而，存活的癌细胞在治疗间隔期也会增殖，这种再增殖过程是治疗失败的一个重要原因。为克服再增殖而制定的策略改善了临床疗效，现在随着对潜在生物学机制认识的进展，抑制再增殖的新策略也在不断涌现。
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