Van der Geest J N, Lagers-van Haselen G C, van Hagen J M, Brenner E, Govaerts L C P, de Coo I F M, Frens M A
Department of Neuroscience, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands.
Exp Brain Res. 2005 Oct;166(2):200-9. doi: 10.1007/s00221-005-2355-1. Epub 2005 Jun 18.
Patients with Williams-Beuren Syndrome (WBS, also known as Williams Syndrome) show many problems in motor activities requiring visuo-motor integration, such as walking stairs. We tested to what extent these problems might be related to a deficit in the perception of visual depth or to problems in using this information in guiding movements. Monocular and binocular visual depth perception was tested in 33 patients with WBS. Furthermore, hand movements to a target were recorded in conditions with and without visual feedback of the position of the hand. The WBS group was compared to a group of control subjects. The WBS patients were able to perceive monocular depth cues that require global processing, but about 49% failed to show stereopsis. On average, patients with WBS moved their hand too far when no visual feedback on hand position was given. This was not so when they could see their hand. Patients with WBS are able to derive depth from complex spatial relationships between objects. However, they seem to be impaired in using depth information for guiding their movements when deprived of visual feedback. We conclude that the problems that WBS patients have with tasks such as descending stairs are not due to an inability to judge distance.
患有威廉斯-贝伦综合征（WBS，也称为威廉斯综合征）的患者在需要视觉-运动整合的运动活动中存在许多问题，比如上下楼梯。我们测试了这些问题在多大程度上可能与视觉深度感知缺陷或在引导运动时使用该信息的问题有关。对33名WBS患者进行了单眼和双眼视觉深度感知测试。此外，在有和没有手部位置视觉反馈的条件下记录了向目标的手部运动。将WBS组与一组对照受试者进行了比较。WBS患者能够感知需要全局处理的单眼深度线索，但约49%的患者未能表现出立体视觉。平均而言，当没有手部位置的视觉反馈时，WBS患者的手移动得太远。当他们能看到自己的手时情况并非如此。WBS患者能够从物体之间复杂的空间关系中得出深度。然而，当被剥夺视觉反馈时，他们在利用深度信息引导运动方面似乎存在障碍。我们得出结论，WBS患者在诸如下楼梯等任务中出现的问题并非由于无法判断距离。
