Department of General Pediatrics, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands.
Cerebellum. 2011 Mar;10(1):14-21. doi: 10.1007/s12311-010-0217-2.
The aim of this study was to quantify the frequently observed problems in motor control in Neurofibromatosis type 1 (NF1) using three tasks on motor performance and motor learning. A group of 70 children with NF1 was compared to age-matched controls. As expected, NF1 children showed substantial problems in visuo-motor integration (Beery VMI). Prism-induced hand movement adaptation seemed to be mildly affected. However, no significant impairments in the accuracy of simple eye or hand movements were observed. Also, saccadic eye movement adaptation, a cerebellum dependent task, appeared normal. These results suggest that the motor problems of children with NF1 in daily life are unlikely to originate solely from impairments in motor learning. Our findings, therefore, do not support a general dysfunction of the cerebellum in children with NF1.
本研究旨在通过三项运动表现和运动学习任务，量化 1 型神经纤维瘤病（NF1）中经常观察到的运动控制问题。将一组 70 名 NF1 患儿与年龄匹配的对照组进行比较。正如预期的那样，NF1 患儿在视动整合方面存在明显问题（Beery VMI）。棱镜诱导的手部运动适应似乎受到轻微影响。然而，在手眼运动的简单准确性方面并没有观察到明显的损伤。此外，眼跳运动适应（依赖于小脑的任务）似乎正常。这些结果表明，NF1 患儿日常生活中的运动问题不太可能仅仅源于运动学习受损。因此，我们的发现并不支持 NF1 患儿小脑普遍功能障碍。
