van der Geest J N, Lagers-van Haselen G C, van Hagen J M, Govaerts L C P, de Coo I F M, de Zeeuw C I, Frens M A
Department of Neuroscience, Erasmus University Rotterdam, P.O. Box 1738, Erasmus MC, DR 3000, Rotterdam, The Netherlands.
Neuropsychologia. 2004;42(5):569-76. doi: 10.1016/j.neuropsychologia.2003.11.003.
Numerous studies have described the poor visuo-spatial processing capacities of subjects with Williams-Beuren syndrome (WBS), a genetically based developmental disorder. Since visual perception and eye movements are closely related we hypothesized that the poor visuo-spatial processing capacities of subjects with WBS might be related to a poor saccadic control. Thereto, we recorded horizontal and vertical saccadic eye movements to targets using infrared video-oculography in 27 subjects with WBS and eight healthy controls. In the WBS group saccadic gains were highly variable, both between and within individual subjects, and they often needed more than one correction saccade to reach the target. Ten (out of a subgroup of 22) WBS subjects showed a large number of hypometric and/or hypermetric saccades, and, also a left-right asymmetry in saccadic gains was observed in WBS. We conclude that the observed impairments in saccadic control are likely to affect the proper processing of visuo-spatial information.
众多研究描述了患有威廉姆斯-贝伦综合征（WBS）的受试者视觉空间处理能力较差，这是一种基于基因的发育障碍。由于视觉感知和眼球运动密切相关，我们推测患有WBS的受试者视觉空间处理能力较差可能与眼跳控制不佳有关。为此，我们使用红外视频眼动图记录了27名患有WBS的受试者和8名健康对照者对目标的水平和垂直眼跳运动。在WBS组中，眼跳增益在个体之间和个体内部都高度可变，并且他们通常需要不止一次校正眼跳才能到达目标。22名WBS受试者中的10名表现出大量欠测和/或超测眼跳，并且在WBS中还观察到眼跳增益的左右不对称。我们得出结论，观察到的眼跳控制损伤可能会影响视觉空间信息的正确处理。
