Szporn Arnold, Chen Xiaoi, Wu Maoxin, Burnstein David E
Division of Cytopathology, Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA.
Acta Cytol. 2005 May-Jun;49(3):262-4. doi: 10.1159/000326147.
To dewribe the recent detection of collagen balls in cervical-vaginal specimens from 7 women within the previous 2 years.
Papaniolaou-stained cervical-vaginal specimens, 3 conventional and 4 ThinPreps (Cytyc Corp., Boxborgugh, Massachusetts, U.S.A.), were reviewed due to the presence of structures indistinguishable from collagen balls.
The structures displayed 3-dimensionality, a hyalinized core and a covering of benign-appearing cells,fratures identical to those seen in collagen balls from serous cavity fluids. Averaging 94 x 60 microm, they were similar in size to a human oocyte at ovulation. Their presence did not correlate with any concurrent Pap smear findings or previous medical history.
Since collagen balls have previously been reported to occur only in serous cavity fluids, they are thought to arise at those locations. We propose that collagen balls are transported via the fallopian tube and uterine fundus to the cervix, much in the same way that an ovum is transported to the uterine flindus for implantation. The likelihood of such an event is most probably quite low. The recent finding of 7 cases of collagen balls may correlate with an increased prevalence of collagen balls in peritonealfl uids, thus increasing the probability of their transport to the cervix.
描述在过去两年内对7名女性宫颈阴道标本中胶原球的最新检测情况。
对帕帕尼科拉乌染色的宫颈阴道标本进行检查，其中包括3份传统涂片和4份薄层液基涂片（美国马萨诸塞州博克斯伯勒的Cytyc公司提供），因为标本中存在与胶原球难以区分的结构。
这些结构呈现三维形态，有一个透明变性的核心以及一层外观良性的细胞覆盖，其断裂特征与在浆膜腔液中的胶原球所见相同。它们平均大小为94×60微米，与排卵时的人类卵母细胞大小相似。它们的存在与任何同时期的巴氏涂片检查结果或既往病史均无关联。
由于此前报道胶原球仅出现在浆膜腔液中，所以认为它们起源于那些部位。我们提出胶原球是通过输卵管和子宫底部输送至宫颈，这与卵子被输送至子宫底部进行着床的方式非常相似。这种情况发生的可能性很可能相当低。最近发现7例胶原球可能与腹膜液中胶原球患病率增加有关，从而增加了它们被输送至宫颈的概率。
