Szporn Arnold H, Chen Xiaowei, Wu Maoxin, Sabo Edmond, Burstein David E
Division of Cytopathology, Department of Pathology, Box 1194, Mount Sinai Medical Center, 1 Gustave L. Levy Place, New York, New York 10029, USA.
Acta Cytol. 2005 Jul-Aug;49(4):387-90. doi: 10.1159/000326171.
To describe the detection of collagen balls in peritoneal washings over a 10-year period, revealing an unexpected and unexplained higher incidence than in the past.
Reports of routinely processed, Papanicolaou-stained smears and cytospins and hematoxylineosin-stained cell blocks from peritoneal washes and ascitic fluids seen over an 8-year period (1995-2002) were reviewed, and the percentage of specimens in which collagen balls were noted was determined. To rule out a learning curve phenomenon, the first 100 consecutive peritoneal washings and ascitic specimens from years 1993-2001 plus 2002 were rescreened, and the percentage of specimens containing collagen balls was determined.
The percentages of cases with collagen balls increased steadily beginning with 8 of 467 cases (3.2%) in 1995 to 185 of 650 (28.5%) in 2002, as reported in the case records. Rescreened cases also showed a similar increase, 4.0% in 1993 to 29% in 2002. No procedural modifications were made in specimen processing during this interval, nor are we aware of any procedural change in obtaining cytologic samples.
An unexplained 7-fold increase in the percentage of peritoneal samples with collagen balls occurred over a 10-year period. This increase cannot be attributed to changes in specimen handling or to a learning curve phenomenon. This finding is of unknown significance and may warrant further investigation.
描述在10年期间对腹膜灌洗液中胶原球的检测情况，发现其发生率比过去意外且不明原因地更高。
回顾了8年期间（1995 - 2002年）对常规处理的巴氏染色涂片、细胞离心涂片以及腹膜灌洗液和腹水的苏木精 - 伊红染色细胞块的报告，并确定了发现胶原球的标本百分比。为排除学习曲线现象，对1993 - 2001年加上2002年的前100例连续腹膜灌洗液和腹水标本进行了重新筛查，并确定了含有胶原球的标本百分比。
病例记录显示，有胶原球的病例百分比稳步上升，从1995年467例中的8例（3.2%）增至2002年650例中的185例（28.5%）。重新筛查的病例也显示出类似的增加，从1993年的4.0%增至2002年的29%。在此期间，标本处理未进行程序修改，我们也不知道在获取细胞学样本方面有任何程序变化。
在10年期间，腹膜样本中含有胶原球的百分比出现了不明原因的7倍增长。这种增长不能归因于标本处理的变化或学习曲线现象。这一发现意义不明，可能值得进一步研究。
