Kronick Mel N
BioResearch Solutions, Agilent Technologies, Inc., 3500 Deer Creek Road, Palo Alto, CA 94304, USA.
Expert Rev Proteomics. 2004 Jun;1(1):19-28. doi: 10.1586/14789450.1.1.19.
Several companies have recently announced the availability of products that enable a scientist to probe gene expression from the entire human genome on a single DNA microarray. This review will focus on the underlying technological trends that have made this achievement possible, the particular methodologies which are employed to create such microarrays and the implications of the whole human genome microarray for future biological studies. The single genome array represents an important milestone on the path to unraveling the complexity of the cellular networks that control living processes. The microarrays being designed today may, however, become distant ancestors to the whole human genome arrays of the future as our understanding of the functioning of the human genome increases.
最近，几家公司宣布推出了一些产品，这些产品能让科学家在单个DNA微阵列上探测整个人类基因组的基因表达情况。本综述将聚焦于使这一成果成为可能的潜在技术趋势、用于制造此类微阵列的具体方法，以及全人类基因组微阵列对未来生物学研究的影响。单基因组阵列是在揭示控制生命过程的细胞网络复杂性道路上的一个重要里程碑。然而，随着我们对人类基因组功能理解的加深，如今正在设计的微阵列可能会成为未来全人类基因组阵列的远祖。
