Wheelan Sarah J, Martínez Murillo Francisco, Boeke Jef D
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Mol Biosyst. 2008 Jul;4(7):726-32. doi: 10.1039/b706237k. Epub 2008 Apr 17.
The efficacy of microarrays in examining gene expression, gene and genome structure, protein-DNA interactions, whole-genome similarities and differences, microRNA expression, methylation (and more) is no longer in question. It is a fast-developing, cutting edge technology that has grown up along with massive sequence databases and is likely to become part of everyday patient care. Many advances have recently expanded the power and utility of microarrays; among them is our development of a new array tiling technique that dramatically increases the scope of coverage of an oligonucleotide tiling array without substantially increasing its cost.
微阵列技术在检测基因表达、基因与基因组结构、蛋白质 - DNA 相互作用、全基因组异同、微小 RNA 表达、甲基化（等等）方面的功效已毋庸置疑。它是一项快速发展的前沿技术，伴随海量序列数据库一同成长，且很可能会成为日常患者护理的一部分。最近有许多进展扩展了微阵列技术的能力和实用性；其中包括我们开发的一种新的阵列平铺技术，该技术能在不显著增加成本的情况下大幅扩大寡核苷酸平铺阵列的覆盖范围。
