Orchard Sandra, Taylor Chris, Hermjakob Henning, Zhu Weimin, Julian Randall, Apweiler Rolf
EMBL Outstation, European Bioinformatics Institute, Wellcome Trust, Genome Campus, Hinxton, Cambridge, UK.
Expert Rev Proteomics. 2004 Aug;1(2):179-83. doi: 10.1586/14789450.1.2.179.
The generation of proteomic data is becoming ever more high throughput. Both the technologies and experimental designs used to generate and analyze data are becoming increasingly complex. The need for methods by which such data can be accurately described, stored and exchanged between experimenters and data repositories has been recognized. Work by the Proteome Standards Initiative of the Human Proteome Organization has laid the foundation for the development of standards by which experimental design can be described and data exchange facilitated. The Minimum Information About a Proteomic Experiment data model describes both the scope and purpose of a proteomics experiment and encompasses the development of more specific interchange formats such as the mzData model of mass spectrometry. The eXtensible Mark-up Language-MI data interchange format, which allows exchange of molecular interaction data, has already been published and major databases within this field are supplying data downloads in this format.
蛋白质组学数据的生成正变得越来越高通量。用于生成和分析数据的技术及实验设计都日益复杂。人们已经认识到需要有方法来准确描述此类数据，并在实验人员和数据存储库之间进行存储和交换。人类蛋白质组组织的蛋白质组标准倡议所开展的工作为制定标准奠定了基础，通过这些标准可以描述实验设计并促进数据交换。蛋白质组学实验最小信息数据模型描述了蛋白质组学实验的范围和目的，并涵盖了更具体的交换格式的开发，如质谱的mzData模型。可扩展标记语言 - 分子相互作用数据交换格式已发布，该格式允许交换分子相互作用数据，并且该领域的主要数据库都在以这种格式提供数据下载。
