Orchard Sandra, Kerrien Samuel
EMBL - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Methods Mol Biol. 2010;604:309-18. doi: 10.1007/978-1-60761-444-9_21.
Molecular interactions are crucial components of the cellular process. In order to understand this complex machinery, one needs to gather published data from various sources. Many projects have initiated the collection of interaction data for this purpose since 2002. However, the lack of standardisation previously made the task of aggregating datasets difficult. This issue has been resolved by the creation of Molecular Interaction standard in 2004 by members of the Proteomics Standards Initiative (PSI), a work group of the Human Proteome Organization (HUPO). Furthermore, major database providers have come together with the goal to exchange data in order to optimise laborious curation tasks. Finally, tools and frameworks have been created based on PSI-MI standards to facilitate the visualisation and analysis of molecular interaction data.
分子相互作用是细胞过程的关键组成部分。为了理解这一复杂机制，人们需要从各种来源收集已发表的数据。自2002年以来，许多项目已为此启动了相互作用数据的收集工作。然而，此前缺乏标准化使得聚合数据集的任务变得困难。蛋白质组学标准倡议组织（PSI）的成员于2004年创建了分子相互作用标准，从而解决了这个问题。PSI是人类蛋白质组组织（HUPO）的一个工作组。此外，主要数据库提供商已携手合作，目标是交换数据，以优化繁琐的整理任务。最后，基于PSI-MI标准创建了工具和框架，以促进分子相互作用数据的可视化和分析。
