Vimalachandran Dale, Costello Eithne
Division of Surgery & Oncology, University of Liverpool, 5th Floor Duncan Building, Daulby St., UK.
Expert Rev Proteomics. 2004 Dec;1(4):493-501. doi: 10.1586/14789450.1.4.493.
Pancreatic ductal adenocarcinoma is a devastating disease that represents an important health problem. It spreads rapidly at a time when patients have relatively few symptoms and consequently is often only detected at an advanced stage when treatment options are limited. Rapid developments in technology and bioinformatics have recently led to a surge in proteomics-based cancer research. Comparative analysis of protein profiles from nonmalignant and malignant pancreas cells or tissue, or from different stages of pancreatic cancer, potentially offer unique insight into the biology of this tumor type. Furthermore, proteomic approaches may provide novel diagnostic or therapeutic markers for this disease. Although such analyses are still in their infancy, they show great potential in the ongoing battle against this dismal disease.
胰腺导管腺癌是一种极具毁灭性的疾病，是一个重要的健康问题。它在患者症状相对较少时迅速扩散，因此常常仅在治疗选择有限的晚期才被发现。最近，技术和生物信息学的快速发展导致基于蛋白质组学的癌症研究激增。对非恶性和恶性胰腺细胞或组织，或胰腺癌不同阶段的蛋白质谱进行比较分析，有可能为这种肿瘤类型的生物学特性提供独特见解。此外，蛋白质组学方法可能为这种疾病提供新的诊断或治疗标志物。尽管此类分析仍处于起步阶段，但它们在与这种可怕疾病的斗争中显示出巨大潜力。
